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Prorenin (inactive), Angiotensinogen, Angiotensin Converting Enzyme (ACE)…
Prorenin (inactive)
Renin (active)
Catalyze
Stored in JG Cells
Angiotensinogen
Angiotensin 1 (peptide)
Angiotensin 2
Direct effect
Blood vessels
Angiotensin 2 has type 1 receptor in blood vessels
Constricts blood vessels
Increase Total peripheral resistance
Increase blood pressure
Kidney
Glomerulus
Constricts efferent arteriole
Increase Glomerular hydrostatic pressure
Increase Glomerular filtration rate (GFR)
Proximal convoluted tubule
Stimulate Na+ H+ exchanger
Increase Na+ reabsorption
Indirect Effect
Adrenal cortex
release Aldosterone
principal cells of kidney
stimulates Na+ K+ ATPase & epithelial Na+ channel
Increase Na+ reabsorption
, K+ secretion
Hypothalamus
Posterior pituitary gland
Stimulates
release of ADH
puts in
aquaporin channels
in principal cells of kidney
Increase H2O reabsorption
Hypothalamic thirst centre
Increase thirst
Increase water intake
produced by Liver
Angiotensin Converting Enzyme (ACE)
predominantly @ Lung