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Aminoglycosides-bind to the ribosome which interferes with bacterial…
Aminoglycosides-bind to the ribosome which interferes with bacterial protein synthesis and leads to defective bacterial membrane
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Gentamicin (IV, IM, topical, othal.)
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Tobramycin (IV, IM, inhaled, opthal.)
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Coverage: Gm (-), Gm (+) for synergy, pseudomonas
Nephrotoxicity, ototoxicity, NMB, fetal harm
Drug level (before 4th dose), renal fctn, balance deficits