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Schizophrenia. ., Ct/ mri
1) Dilatation of lateral n 3rd ventricle
2)…
Schizophrenia. .
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History
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T J Crow
Type 1
acute<2 weeks
Abrupt
good prognosis
positive symptoms
fam h/o Affective disorders
emotions +
ct/mri findings +
precipitating factors +
Type 2
chronic
2 weeks
insidious
bad prognosis
Negative symptoms
Fam h/o schizo
emotions —
ct/mri findings —
precipitating factors —
Kurt Schneider
AUDITORY HALLUCINATIONS
Voices arguing or discussing 3rd person - diagnostic
voices commenting on person's actions - running commentary
Audible thoughts - Thought echo,
echo de pemes,
thought sonorization,
Geden Kenlaut Werden
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Diagnosis
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I CD → for Dx symptoms mustbe
Im
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Prevalance
Gen 1%
child with one parent 12%
child with 2 40%
non twin sibling 8-10%
dizygotic twin 12%
momozygotic twin 50%
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Etiology
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Glutamate, GABA&
Seratonin
Glutamate: NMDA receptors
1 Ketamine Phencyclindine.> decrease
- Cocaine Amphetamine > increase
Both produce schizophrenia likesymptoms
Prognostic factors
Good
Female
45y
married
catatonic>paranoid
Bad
Male
early onset
unmarried
hebephrenic schizo
worst simple schizo
schizoid personality
soft neurological sign
TREATMENT
Antipsychotics
1st generation
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EXTRAPYRAMIDAL SYMPTOMS
Acute muscle dystonia
- Torticolis
- Trismus
- Oculogyric crisis
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Non Pharmacotherapy
CBT
Social skill training
Cognitive enhancement/ cognitive remediation therapy
Token economy( =contigency Mx)
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