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Adaptive Immunity
CMI - Coggle Diagram
Adaptive Immunity
CMI
Features of CMI
Antigen
Definition:
- Substance that generates specific immune response, induces formation of specific Ab or specially sensitized T cells or both
- Can be recognized by antigen receptor of BCR and TCR when complexed with MHC
B cells/T cells
- Antigen reaction - BCR bind free Ag in solution/TCR binds antigenic peptides bound to MHC
- Nature of antigen - Protein, Polysaccaride, lipid
- Binding soluble antigen - yes/no
- Epitopes recognized - accessible, sequential or non-sequential, confirmational/internal linear peptides produced by antigen processing
Epitope location - Outside molecule/Bind on MHC
Antigen processing for MHC class 1
- Endogenous antigens
- Derived from pathogens
- Occur in cytoplasm
- Peptide transported from cytoplasm into endoplasmic reticulum bind to newly synthesized MHC 1
Antigen processing for MHC 2
- Exogenous antigen
- Pathogen that does not injure host
Cross presentation of MHC 1
- Presentation of internalized antigens on MHC 1 molecules
APC involves in generating peptides
- Present antigens on MHC 1 to CD 8 T cells
- DC take exo antigens by either phagocytosis or pinocytosis
APC
- Able to endocytose antigens, degrade and present antigen fragment on the cell surface in association with MHC protein to T lymphocytes and activate them
- MHC 1, CD8+ T
- MHC 2, CD4+ T
MHC
Low expression of MHC class 1
- Usually occur in viral infected
- Virus synthesize protein inhibit the synthesize of MHC class 1
- Tumor cells show decreased expression of MHC 1, reducing potential antitumor response by CD8+ T cell
- Low MHC 1 presentation triggers response of NK cells
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