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DNA repair, replication,and recombination - Coggle Diagram

- - - - Links sister chromosomes to properly segregate them between self and daughter cells
      - genetic diversity
      - DNA repair
    - - Replication fork encounters damage in
        template strand
      - Replication fork collapses due to creation
        of a double-strand break
    - - RuvB
      - RuvC
        
        Holliday Junction Is Cleaved by RuvC
        
        it is a nuclease
        
        Binds to RuvAB complex
        
        DNA ligase seals the nick
      - RuvA
        
        binds where four arms of Holliday
        junction come together
    - - meiosis:diploid germ cells divide to haploid cells
      - separate
        daughter cells at meiosis I
      - Recombination Links Sister Chromatids Together
      - Crossing-Over/Recombination in Meiosis
      - Homolgous Recombination and
        Gene Mapping
      - Improper Segregation of Chromosomes
        
        containing two copies =trisomy(down syndrome)
        
        containing no copies = monosomy(Turner’s syndrome)
        
        Aneuploidy(非整倍體)=wrong # chromosomes
  - - - Inversion or deletion( on the same DNA)
      - Intermolecular recombination(pn different DNAs)
      - • Insertion( DNA is circular)
    - - Resolution of Holliday junction can create
        dimeric DNAs
      - converts dimer into monomers
    - - Entire transposon is replicated
    - - Kappa Chain V, J, and C Segments
        Undergo Recombination
        
        1,200 possible V-J arrangements
        
        3,000 possible combinations
        
        1.5 * 10-7 possible IgG molecules
      - Recombination signal sequences (RSS) are found
        between the V and J segments
      - Recombination between clusters of these genes
        produces different antibodies
      - Two heavy, two light polypeptide chains