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Thymus - Coggle Diagram
Thymus
Adult function
Extra-thymic thymic activity
Abnormalities of athymic patients
abnormalities in late athymic mice
Immune repertoire adaptation
Compensation for mosaicism
thymic rejuvenation
immune boosting
Sex steroid ablation
IL-22
Standalone therapy
sex steroid ablation
autoimmune regulation
extra-thymic upregulation
Hassal's corpuscules
Thymic endocrine function
thymosin
thymulin
thymopoietin
thymic humoral factor
Antigen census
Promiscuous gene expression
PGE in non-mTECs
Overexpression of genes by PGE
Enhance activity toward unexpressed antigens
PGE for tumor sensitization
whole-body translatome
Brain and testes expression of AIRE?!
Link b/w immune privilege and AIRE
Non epithelial APCs
Changes in antigen census over time
Immune system modulation
Allergy/autoimmunity prevention
Reactivity "moats" around friendly antigens
Negative selection of reactive T cells
Selection at/before birth
Selection after birth
Induction of antigens in thymus
Adult T cell selection
Retraining
Turnover
Cytotoxic conditioning
Antigen/disease space
Autoimmunity
Allergy
Allogenic transplant
Route of administration
Local intrathymic injection
Peripheral
Cell localization
thymic seeding progenitors
Nanoparticle
Unique thymic uptake
Blood supply
Extra-thymic target
liver
spleen
Payload
mRNA
Other
Proteins
Cytokines
Virus
Cells
Tregs mediated tolerance
T cell retraining for tolerance
Gut biome-mediated tolerance
Receptor selection
Receptor design
Protein design
T cells that do not bind MCH
Gain of function in thymomas
Myasthenia gravis
Tr cell differences
Thymus as part of lymph network