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regulation of gene expression - Coggle Diagram
regulation of gene expression
operons
lac operon in E coli
lactose must be present to reduce repression
glucose must be in low concentration to activate the process
trp operon
trp in low concentration
segment 2 and 3 pairs
trp synthesis
trp level is high
segment 3 and 4 pairs
forms attenuator structure
housekeeping gene
expressed in almost every cell
regulated gene
genes being inducible and repressible
RNA polymerase binding to promoters is a major of gene regulation
negative regulation and positive regulation
negative regulation involves repressors
positive regulation involves activators
bacteria enhancers are usually adjacent to promoter,while eukaryote enhancers may be far away from it due to DNA looping
protein DNA binding motifs
helix turn helix
specific contacts between the recognition helix and the major groove
zinc finger
interacts with DNA or RNA
binding is weak ,so several zinc fingers often act in tandem
leucine finger
DNA binding domain has basic residues to interact with polyanionic DNA
SOS response and viral propagation
some repressors keep viruses in a dormant state in bacterial host
translational feedback is performed in protein operons
DsrA RNA promotes translation
OxyS RNA inhibits translation