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Anti-Helmintic Drugs, Tissue Cestode Echinococcus granulosus (dog tw) …

- - - - Uses – DOC – lymphatic filariasis - Wuchereria bancrofti, Brugia malayi, B timori - Kills both microfilaria (killed immediately) & adult worms (require prolonged therapy – 12-21 days).
        
        Tropical pulmonary eosinophilia
    - - MOA - ↑transmission thro Glutamate-gated Chloride channel → hyperpolarization, paralysis, death
        
        Uses - DOC - cutaneous larva migrans, Strongyloides & onchocerciasis
        
        Oral single dose treatment for lice & scabies (0.2 mg/kg)
        
        C/I pregnancy & children <5 years age
        
        ADRs – Mazotti reaction – due to killing of microfilaria – fever, headache, dizziness, somnolence, hypotension.
  - - - Thiabendazole - only topical for cutaneous larva migrans
      - Albendazole
        
        Single dose 400mg for soil transmitted helminths
        
        DOC – Taenia solium, hydatid disease, neurocysticercosis – 400mg BD for varying duration
        
        ADRs on prolonged dosing - hepatotoxic, agranulocytosis, pancytopenia
- - - - Except
        Fasciola hepatica – Triclabendazole preferred
        Hydatid disease – Albendazole preferred