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Adaptive immunity T cells - Coggle Diagram
Adaptive immunity T cells
Clonal selection + role of effector cells in cell mediated and humoral responses
Cells that have rearranged the right gene segments bind antigen. Antigen binding triggers cell division. This is
clonal expansion
Clonal expansion generates large numbers of cells making the same receptor - the other cells die
Function of T cells and how they contribute to adaptive immune response
when T cell has right antigen to bind it goes through clonal selection
T-cell mediated immunity is very important for B cell help and in anti-viral immunity
GENE REARRANGMENT is key to adaptive immunity
allows immune system to adapt
allows you to acquire an immune response
T and B cells rearrange genes at random (10 million every day)
T cell maturation, activation and differentiation
mature in the thymus
Activation
Antigen
Presentation of antigen to MHC molecule on antigen-presenting cell
Constimulation
CD28 binds to B7 on APC
IL-2 factor to be produced which stimulates clonal selection
differentiation
VDJ recombination = this is what provides T cell diversity
and allows us to fight so many infections
T helper cell subtypes
Th1
fights intracellular infections
Macrophages and natural killer cells
Th2
Fights parasites using eosinophils, basophils and mast cells
T helper type XVII fights fungal and bacterial infections
I think it produces IL-1 which up-regulates IL-2 alpha receptor so when one of the helper cell binds other immune cells comes or soemthing
T follicular helper (Tfh) establishes memory B cells