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regulation of gene expression 2 - Coggle Diagram
regulation of gene expression 2
RNA Polymerase II Requires
Five Types of Proteins
Chromatin modification/remodeling proteins
Coactivators
Architectural regulators
facilitate DNA looping
promoter link to enhancers
Basal (general) transcription factors
Transcription activators (enhancers)
proteins that bind to upstream activator sequences
Yeast Galactose Metabolism
GAL: Genes for galactose metabolism
all have similar promoters
Gal4 protein
Galactose binds Gal3p, then forms a complex
with Gal4p and Gal80p
It allows Gal4p to be activator
Gal4 also recruits the SWI/NSF and mediator
complexes for opening the chromatin
Hormone-Mediated Regulation
hormone response elements
(HREs)
: Hormone-receptor complex binds to DNA
regions
bind DNA:zinc fingers
Hormone Receptors
type 1
sex hormones and
glucocorticoids
hormone-receptor complex
travels to nucleus
hormone bind with Hsp70
type 2
thyroid hormone
receptor
found in nucleus bound
to DNA