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Pituitary Disorders - Coggle Diagram

- - - - Persisting epiphyseal plates
- - - - If stops drinking = primary polydypsia
      - If continues = urinalysis, water deprivation test followed by desmopressin response test
        
        USG < 1.008
        
        USG will be fixed and unchanging
        
        Patient must become dehydrated - 5% reduction in body weight, increased PCV/TS or increased sodium or urea
        
        Administer desmopressin IM/IV 2-10ugm/animal
        
        USG >1.020 within 4 hours
        
        Allow limited water (50-100ml/kg/24hrs)
        
        Treatment
        
        DDAVP conjunctively 1-4 drops per patient q12-24hrs - tapered to effect
- - - - Insulin resistance
      - Tissue proliferation
      - 1000ng/ml
  - - - Growth hormone producing mammary tissue
      - Associated with dysmenorrhea
  - - - Acromegalic
      - Markedly hyperglycaemic with elevated fructosamine
    - - Agressive insulin treatment
      - Radiotherapy
      - Hypophysectomy
        
        £5-6000
        
        If tumour not too large
        
        High chance of achieving diabetic remission
        
        Dependent on skilled team and appropriate perioperative care
        
        BID insulin
        
        SID thyroxine (20ug/kg)
        
        SID cortisone (0.25mg/kg)
        
        SID DDAVP peri-ocularly
      - Pasireotide injections
        
        Multi-receptor somatotroph antagonist