Christopher Columbus, an explorer navigator, a conqueror who, together with 120 men and 3 ships, began a journey that would change the history of the world.
On his first trip, it is believed that the first lands visited by the Spanish were the Guanahani Islands, which he baptized as San Salvador.

They arrive at Panamanian coasts on their fourth voyage, traveling from Cabo Gracias a Dios in Honduras to the Isthmus of Panama.
They arrived at Almirante Bay on October 6, 1502.

The continental territory was divided into 2 entities for the conquest and colonization, this mission would be given to the knights Alonso de Ojeda, who was entrusted with the eastern part called Anda Lucía and Diego de Nicuesa the western part with the name of Castilla de oro.

First city on the mainland in the American continent, located in the Caribbean Sea in the Darién region, It was founded by Vasco Nuñez de Balboa in the year 1510.

An expedition to search for Nicuesa, arrived in the name of God, finding Governor Niecuesa in a pitiable state, as a result of hunger, disease and constant confrontation with the indigenous people. On March 1, 1511, Nicuesa was transferred to a ship in bad conditions. conditions and without sufficient provisioning and they left it in the sea.

Vasco Nuñez de Balboa undertakes an expedition trip from Santa Maria in search of the famous sea, despite various difficulties they entered the chucunaque river ranges, and from the top they could see the sea, this discovery was on September 25, 1513.

He was the new governor for Castilla de Oro, among the instructions given, he arranged to found towns, carry out expeditions to the Darién, he died on March 6, 1531 at the age of 91.

It was that of Santa Maria de la Antigua del Darién, created by Pope Leo X through the Bull "Pastoralis Offici" of August 28, 1513.

Panama was founded on August 15, 1519 by Pedrarias Dávila.
Emperor Crlos V granted the title of city to Nombre Dios on December 77, 1519.

Since the arrival of Christopher Columbus to the isthmus, there were many conflicts with the indigenous people, taking the worst part, many were displaced from their territory until they disappeared. The Urraca Indian stands out, who dominated the lands of Veraguas and was one of those who fought and resisted the Spanish expeditions for almost 9 years.

The Spaniards continued their route of conquest to other points touring the provinces of Chiriqui and Veraguas, then they reached the lands of chief Nata.

On November 14, 1524, the first of three expeditions led by PIZARRO departed for Peruvian lands. However, it did not reach its destination. The second expedition left Panama in 1526, which had various setbacks.
With an expedition of 280 men, PIZARRO left Panama again in 1531, managing to dominate Inca lands.

In 1536, LUIS COLÓN, grandson of the Admiral, received from Emperor CARLOS V, an area of ​​25 square leagues in the region that today occupies the Province of Veraguas. This territory was given the
Duchy of Veraguas nomenclature.

Studies were made to take advantage of the flow of the Chagres River, during the mandate of Governor PEDRO DE LOS RIOS, exploring the Chagres River and the Grande River, the project consisted of using the navigable waters of the Chagres River and the connection with the Grande River.