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Malaria - Coggle Diagram

- - - - The endothelial protein C receptor involved in the sequestration of parasitized erythrocytes
  - - - P. falciparum→ avoid passing through
        spleen and can multiply reaching high concentrations
        
        The spread is greater when the parasites are found in areas with less oxygen
        
        Something important about the pathogeny
        
        PfEMP-1
        
        antigenic variant protein family
        
        VAR
        
        It is considered that on the surface of an erythrocyte infected, a single variant is predominantly expressed
        
        The exposed PfEMP-1 proteins show binding regions that are
        bind to host molecules such as CD36, (ICAM-1), thrombospondin, (PECAM/CD31)
        
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