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Eukaryotic RNA polymerase, Nuclear geans, :, Suzan albordaini 201703178,…

- - - - Rpb6
      - Rpb8
      - Rpb12
      - Rpb10
      - Rpb5
      - play role fundemental to transcription procrss (rate, strongful)
    - - Rpb4
      - Rpb9
    - - Homolougus to B' , B, alfa in bacteria
        
        Rpb2
        
        (B) - Active site
        
        Rpb3
        
        (alfa) - orthlog alfa dimers
        
        similarity
        
        2 monomer per holenzyme
        
        20 aa region similirity
        
        2 subunit with same size and stoichimetry
        
        Homologous to bacteria
        
        Rpb1
        
        (B') - CTD , binds DNA
        
        ll a (215kp)
        
        bind to promoter (initiation) , hypo-phosphorylated
        
        ll o (240kp)
        
        involved transcipt elongiation , hyper-phosphorelated
        
        ll b (180kp)
        
        proteolytic removel of CTD
    - - stress response interact with Rpb4
    - - alfa ortholog interact with Rpb3