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SLE - Coggle Diagram
SLE
Investigations
FBC, U&E (look for blood abnormalities, renal function), ESR
Autoantibody screen: ANA (if positive - antidsDNA, antiSm, antiRNP, anticardiolipin, lupus anticoagulant, C3 & C4)
Urinalysis, metabolic screen
DDx
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Endocarditis, HIV infection, IBD, mixed CT disease
Connective tissue disease: sarcoidosis, systemic sclerosis
Management
rest when disease active
sunblock creams daily
chloroquine 150mg daily (anti-inflammatory, antithrombotic, antilipidaemic effects)
Corticosteroids if severe organ involvement (lowest dose for shortest time necessary)
treat any CVS disease
antiphospholipid syndrome: low dose aspirin
Monitoring
Inactive disease: monitor 4-monthly - examine, BP, dipstick, FBC, liver enzymes if on risky medication.
To check possible flare: complement, dsDNA, CRP
Annual HIV test, lipogram, creatinine
Nephritis
acutely treat with immunosuppressant (eg cyclophosphamide) + glucocorticodes
Maintenance with azathioprine for at least 3 years
Presenting symptoms
Most common
constitutional: fatigue, LOW, fever without focal source
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Less common
malar rash, photosensitivity, pleuritic chest pain, new-onset Raynaud's, mouth sores
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autoimmune disease in which immune complexes deposit in multiple organs causing variable symptoms. Usually a course of flares and remissions.
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