The heart is a muscular pump. Like all muscles, it needs oxygen for aerobic respiration to contract. The coronary arteries supply blood, and therefore oxygen, to the heart muscle.
The coronary arteries may become blocked by a build-up of fatty material, caused by certain kinds of 'bad' cholesterol. As the fatty material increases, one or more coronary arteries narrow, and can become blocked.
If a blockage builds up, the amount of oxygen reaching the heart muscle is reduced. A person will develop chest pain, and if left untreated, a heart attack is the result. This can cause damage to, or death of the heart muscle. Part of the heart muscle, or the whole heart, will die.
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Statins are drugs that help to lower cholesterol in the blood. They do this by lowering its production in the liver.
Statins are prescribed for people with heart disease or who have a high risk of developing it. They need to be taken long-term. Cholesterol levels will rise again if a person stops taking them.
Some studies have raised concerns regarding the side effects of statin use, while others believe they can bring additional positive benefits.
Statins are not suitable for everyone - they should not be prescribed for people with liver disease, or pregnant or breast feeding women.
Some patients taking statins often experience side-effects such as headaches and memory loss. There have been reports of statins being linked with type 2 diabetes and liver damage.
Other people argue that statins should be used more widely. They may protect against other conditions such as Alzheimer's disease, but further research is needed.
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Coronary arteries that are blocked or have become narrow can be stretched open and a stent inserted to restore and maintain blood flow.
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Drugs - statins Reduce the risk of heart attack. Studies have shown a decrease in 'bad cholesterol' and an increase on 'good cholesterol.' Used to reduce high cholesterol levels that have genetic causes. May have beneficial effects on other conditions. Not suitable for people with liver disease. Some side effects. Must be taken for life. Should not be taken if pregnant or breastfeeding.
Heart transplant Improve quality of life. Few donor hearts are available. Recovery time is long. There is a risk of rejection by the body's immune system.
Replacement heart valves Restore blood flow through the heart. Biological valves may wear out. Blood clots may stick to mechanical valves - anti-blood clotting drugs need to be taken.
Stents Widen coronary arteries that have not responded to drug treatment. The recovery time is short following insertion of the stent. In a minority of cases, further treatment is required.