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CONGENITAL ABNORMALITIES OF THE EYE: Aniridia - Coggle Diagram
CONGENITAL ABNORMALITIES OF THE EYE: Aniridia
Signs and symptoms
Reduced vision
Nystagmus
Absence of iris
Strabismus
Causes
Patients with Aniridia who have a positive family history
As an isolated ocular malformation, Aniridia is an autosomal dominant disorder, which is caused by a mutation in the paired box gene family gene
An identified chromosome deletion of the short arm of chromosome 11
Diagnostic Studies
Laboratory studies
Histological findings
Defination
It is the absence of iris , usually involving both eyes, it is a congenital, hereditary, bilateral, extreme form of iris hypoplasia that may be associated with other ocular defects
Pathophysiology
The pathogenesis of anirida is attributed to a primary developmental arrest of the neuroectoderm and a secondary alteration of all 3 neural crest waves of the mesenchyme. The functional development of the anterior segment is a complex interrelationship between the neural ectoderm and the neural crest waves of the mesenchyme
Nursing Intervention
Presence of foveal and optic nerve hypoplasia
Degree of iris hypoplasia
Best corrected visual acuity