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Immunomodulation - Coggle Diagram

- - - - Auto-Ig
      - Auto-reactive CD8's
        
        Cytokine overexpression
- - - - T-cell tolerance
    - - Clonal exhaustion
    - - Immunogenic
  - - - Tolergenicity
    - - IM/SC/IV
- - - - Prostanglandins
        Leukotrienes
        
        IL4
        IL13
    - - anti-Ige
      - anti IL5 (eosinophils
        
        Asthma
      - Anti-IL4/IL13
        
        Stim T reg
        asthma and atopic dermatis
    - - Oral
        
        Peanuts
        
        Don't Exercise for 2 hours
      - Topical
  - - - IL-1B
      - TNFa
      - IL-6
        
        Sys Juv Arth
        
        Autoinflammatory d/o
        
        ANA/RF :no_entry:
        
        Quotidian fever (up/down)
        Salmon colored rash
        Hepatosplenomegaly
        
        IL1 blocker then IL6 :pill:
      - CxCL8
      - CTLA4 (Abetacept)
        
        CD28 costimulation
      - CD20 (Rituximab)
        
        B-cells
        
        RA/SLE
      - IL-17
        
        prevent destruction of osteoclast
        prevent keratinocyte plaque
        
        Psoriatic arth
      - IL-12 and IL-23
        
        blocks IL-17 and TNF
        One step before IL-17
        
        Disrupt Cytokines
        
        Crohns
        
        Alt: Helminth therapy
      - JAK3
        
        Block inflammatory cytokines
  - - - mouse/chimeric
    - - Human
- - - - Eradication
        
        Smallpox easy,
        Malaria hard
    - - Only expressed temporarily or minimal concentrations
    - - Stimulates stronger immune response
        
        Aluminum, bacterial products
  - - - Smallpox, measles, polio
    - - Shigellosis, cholera, malaria
    - - Gonorrhea
    - - TB, salmonellosis
  - - - Tetanus
        
        antigen/carrier protein
    - - Hep B
        
        Recombinant with yeast
    - - COVID
    - - HPV
        
        L1 monomers and assembled into capsomerse
- - - - Costim/Cytokines
        B7
        CD80-86
        
        IL-2
        
        Apoptosis
      - CD80/86 w/
        CTLA4 inhibits
        IL-2
        
        Arrest
- - - - DM I
        
        CD8 cells on B islet cells
      - RA
        
        Rh facter reative to IgG
        
        Treated with TNF-a blockers
        
        Reactivate TB
      - Pernicious anemia
        
        Intrinsic factor absorbs B12
        this is disrupted
      - SLE
        
        Photosensitivity
        
        rash, arthritis, GN