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Antifungals - Coggle Diagram

- - - - Poor CNS penetration
        Leaks Cation
        Lipid vs Liposomal
        liposomal (higher dose, less neprhrotoxic)
      - Toxicity:
        Nephrotoxicity
        Hypersensitivity reactions w/
        electrolytes abnormalities
      - Candida
        Cryptcoccus
        Aspergillus
        Mucor
    - - Topical use, not systemic
      - Used for topical yeast
  - - - Toxicity:
        Antiandrogenic (testosterone)
        Strong P450 inhibitor
      - Good to Boost P450
    - - Cryptococcus maintenance
        Go to yeast drug
        :no_entry: for mold
        or Aspergillus
      - Wide therapeutic index
    - - Endemic mycoses (histo)
        Aspergillus
      - Very poor CNS penetration
        low oral bioavailability
      - QTc elongation
        P450 Inducer
        Capsules need acid, stop PPI's
    - - Hepatotoxicity, skin photosensitvity, hallucinations
        Skin Cancer/flouride induced periositits
      - Contra: Renal insufficiency
      - No mucor coverage
    - - Posaconazole,
        
        Hyperaldosteronism
        
        Candida
        Aspergillus
      - Isavuconazole
        
        Covers mucor
      - candida
        Aspergillus
        mucor
      - Terbinafine
        
        Dematophyte coverage
        plus yeast and mold
        better the Griseofulvin
        
        Squalene epoxidase
        Upstream targeting
        
        Highly lipophillic, stays in skin
        nails and fatty tissue