Please enable JavaScript.

Coggle requires JavaScript to display documents.

Immunology - Coggle Diagram

- - - - Immediate
    - - delayed
  - - - Self to Self
    - - Twins
    - - Different people
    - - Pig valves
  - - - Small Grafts
        
        Recognition of foreigness
        
        Indirect allorecognition
        
        Taken up by DC then peptide presented
        Recip TCR with Recip MHC
        
        Direct allorecognition
        
        Recipient TCR vs Donor MHC
        
        Primary (vascularized)
        
        Secondary (<7 days, non vascular)
      - Large Grafts
        
        Second organ
    - - Occurs in ALL BMT cases
        Donated plasma cells
      - Both Direct and Indirect
        
        Class I mismatch is most indicative of Death
        
        Recip/Donor Direct
        
        Recip/Recip Indirect
      - Lesions
        
        Skin, GI, Liver, Lung
    - - Hyperacute (mins)
        Type II
        
        preformed Ig
      - Accelerated (Days)
        Type IV
      - Acute (Days/Weeks)
        
        CD4/CD8
      - Chronic (months/years
        
        Type IV,II
        Interstitial fibrosis/narrowing
        
        Indirect pathway
        
        Fibrosis in all affected tissues
  - - - Cyclosporin
        
        :small_red_triangle_down:IL-2 Production
      - Aziothioprine + Steroids
        
        :small_red_triangle_down:Purine syn,
        cell division, inflammation
      - Tacro
        
        :small_red_triangle_down: IL-2 promoter
    - - S1P Blocker, T cells can't
        leave lymph nodes
- - - - Tumor
        
        Metastasis
        
        Cancer
        
        Cells de-differentiate
        
        Over expression of MHC
        
        Recognition
        
        Enbryologic peptides
        Overexpression of self
        Mutated protein
        
        Avoid detection
        
        Low immungenicity
        
        tumor treated as self
        
        antigenic modulation
        
        Tumore induced suppression
        
        Physical barrier
        
        Grows independent of
        density or other
        limiting factors
  - - - NK cells
        
        Macrophages
        
        TNF-a
    - - CD8 T cells with CD4
        
        Escaping the CD8
        
        T Regs
    - - Killed tumor vaccines
      - DC Targeting Vaccine
      - Monoclonal Antibodes
        
        opsonize the tumor
        
        CD16 (NK) destroys
      - IL2 Cell expansion
  - - - Challenge with irradiated
        tumor cells for immmunity
    - - Self Reactive T cells run into self antigen
        
        Anergy
    - - temporary suppression of concommitant tumors