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codon usage bias - Coggle Diagram
codon usage bias
factors influencing the CUB
length of gene
context of codon in a gene
expression level
recombination rate
GC content
mRNA folding
genome composition
tRNA abundance
defined as
phenomenon of preferential or non-random use of synonymous codons
A substitution in the 2nd / 3rd nucleotide of the codon
p.s: closely related organisms demonstrated a similar patterns of codon usage
evolved due to
directed mutation
natural selection
genetic drift
potential explanation for CUB
natural selections explanation
.
mutational explanation
bias in the rates or repair of point mutations a
biases in nucleotides produced by point mutations
determine
translation efficiency,
tuning the elongation rate
of translation
mRNA folding
transcription levels
affecting chromatin structures