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FPV - Coggle Diagram
FPV
oronasal exposure of faeces/urine of infected cats
and contaminated formites
entry of virus into oropharynx
replicates in pharyngeal lymphoid tissue
viremia
infect other organs (active dividing cells) & lymphopoietic cells of bone marrow, thymus, lymph nodes and spleen
infected proliferative cells
depletion of myeloid and erythroid elements
hypocellularity
leukopenia
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intestine
virus replicate & infect epithelial cells lining crypts of Lieberkuhn
damage crypt cells
release from infected crypt enterocytes and affect Peyer's patches + mesenteric lymph node
blunting and shortening of intestinal villi
malabsorption
diarrhea & vomit
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Weak immunity at GIT area
Salmonellosis or Tyzzer disease
Bacteremia
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Pregnant cat, intrauterine infection
transmit to growing embryo
cerebellar hypoplasia, optic nerve hypoplasia
Pathogenesis