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Risk Assessment - Coggle Diagram
Risk Assessment
Exposure Assessment
2 aspects
Route of exposure
Oral
Gastrointestinal tract
Inhalation
Lungs
Dermal
Skin
Injections
Medicines
Duration & Frequency of Exposure
4 categories
Acute
<24 hrs
Single Dose
Sub-acute
one month or less
Repeated exposure
Sub-Chronic
1-3 months
Repeated exposure
Chronic
3 months
Repeated exposure
Estimated Daily Intake
EDI
Concentration X Consumption= Intake
Terminology
Risk
Hazard x Exposure
Hazards
Potential danger of a cmpd or process
Risk
Probability that an adverse effect will occur
Risk Assessment
Process by which hazards, exposure, and risk are determined
Genotoxic Carcinogens
2 types of cmpds
Non-genotoxic cmpds
Margin of Safety
(ADI)/(EDI) >1
(NOAEL) or (BMDL)/(EDI) > 100
Genotoxic carcinogenic cmpds
Avoidable Contaminats
Zero Tolerance
Cannot be used
Unavoidable Contaminants
ALARA
As low as reasonably possible
VSD
Virtual Safe Dose
Defines dose with acceptable cancer risk
1/ 10^6 consumers
Based on linear extrapolation
MOE
Margin of Exposure
(BMDL10)/(EDI)>10,000
Lower=worse
BMDL10=Bench Mark Dose Level that leads to 10% increase in incidence of disease
Used by risk manager to set priorities
X quantify cancer risk
How derive ADI/TDI of chemical