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Hazard Characterization - Coggle Diagram
Hazard Characterization
Why do we perform Hazard Characterization?
To set safe exposure levels for humans
Accepted Daily Intake
Tolerable Daily Intake
Classification
Labeling
How do we obtain the safe exposure levels
Dose response curve
What is Hazard Characterization?
Used to protect humans from adverse effect from chemical exposure
Based on in vitro and in vivo data
Pro and Con of Data Analysis approaches
Benchmark Dose Approach
BMD
Pro
All data used
Independent of experimental design
Con
No information on no effect level known
No-Observed Adverse Effect Level
NOAEL
Uses ANOVA stat tool
Shows which conc. signif diff from cntrl
T-test
Also looks at
Lowest Observed Effect Adverse Level
LOAEL
Limitation
Can be influenced by study design
Not all data used
Pro
No effect level known
Other methods
Regression Analysis
What are the outcomes of Hazard Characterization?
ADI
for
avoidable
contaminants
Additives
Pesticides
TDI
For
unavoidable
contaminants
Dioxins
Mycotoxins
Heavy Metals
How experiment done?
Expose cells/org to increasing conc. of cmpd
Select endpts to measure
Est best possible test
Data Analysis and Reporting