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TNK - Coggle Diagram
TNK
early
2012 TAAIS
≤6 h, IIb
ACA/MCA/PCA
.25 >TPA in reperfusion
& NIHSS
2015 ATTEST
≤4.5 h
.25= TPA salvage penumbra
2010 TNK-S2B
<3h
.4 higher ICH
2017 NOR-TEST
<4.5 h
.4 =TPA in low NIHSS
2024 TASTE
≤4.5 h
.25 NI to TPA (PP group) in AU
2022 AcT
≤4.5 h
.25 is NI to TPA in efficacy and safety in Canada
2022 NOR-TEST 2A
≤4.5 h
.4 has higher ICH and worse mRS than TPA
2023 TRACE-2
<4.5 h
.25 NI to TPA in China
ATTEST-2
<4.5 h
.25 NI to TPA in UK
ORIGINAL
<4.5 h
.25 NI to TPA in China
bridge EVT
2018 EXTEND-IA TNK
≤4.5 h
ICA/MCA/BA
.25 > TPA recanal
mRS ordinal shift
2020 EXTEND-IA TNK, part 2
≤4.5 h
ICA/MCA/BA
.25 = .4 on reperfusion
BRIDGE-TNK
≤4.25 h
LVO
.25 vs STD
TNK-CAT
≤4.5 h
IC occlusion
.25 vs TPA
DIRECT-TNK
≤4.5 h
ICA/M1-2
NIHSS ≥6
.25 vs pcb
Minor ICASO
2015 TEMPO-1
<12 h, II
IC occlusion
NIHSS 0-5
.1=.25
2024 CHABLIS-T
4.5-24 h
ICA/M1-2/ACA 70-100%
NIHSS 0-5
.25=.32 in reperfusion
w/o SICH
2024 TEMPO-2
<12 h
IC occlusion
NIHSS 0-5
.25 not better but more death than STD
late EVT
2024 TIMELESS
4.5-24 h
ICA/M1-2
.25 not better in function
vs pcb
ETERNAL-LVO
4.5-24 h
ICA/M1-2
.25 vs STD
CHABLIS-T II
4.5-24 h
ICA/M1-2/A1-2
.25 vs STD
Extended
2023 ROSE-TNK
4.5-24 h
DWI-FLAIR mismatch
NIHSS 6-25 or
NIHSS 0-5 +ICA/M1-2/ACA
.25 not better than STD
2022 TWIST
wake-up
NIHSS ≥3
hypodensity <1/3 on CT
.25 not better in mRS or death by CT
vs pcb
2024 TRACE-III
4.5-24 h
ICA/M1-M2
NIHSS 6-25
.25 > STD in mRS
IA TNK
INSIST-IT
≤24 h
BAO
NIHSS ≥6
pc-ASPECTS≥6
0.2-0.3 mg/min for 20-30 min vs STD
TECNO
<345 min
ICA/M1-2 incomplete
TNK vs STD
BRETIS-TNK II
≤24 h
LVO
4 mg bolus+ 2 mg/5min + 3 mg/15 min
ambulance
2022 TASTE-A
≤4.5 h
.25 decr perfusion lesion,
incr clot migration vs placebo