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Haematology - Coggle Diagram

- - - - M protein band with kappa/lambda light chain
    - - increased levels - poor prognosis
  - - - renal failure
      - anaemia
      - osteolytic bone lesions
        
        cord compression can occur
        
        pathological #s
      - hypercalcaemia
    - - blurred vision
      - VTE
  - - - tumour lysis syndrome prophylaxis: allopurinol + hydration
        
        high LDH in tumour lysis syndrome
- - - - blasts cells
      - Auer rods: AML
      - CLL: smear cells (most common leukaemia in adults)
  - - - if CD20 +ve - rituximab
- - - - more common with UFH
    - - deficiency of ADAMTS13
      - schistocytes
      - tx: steroids, plasma exchange
    - - tx: steroids, IVIG, immunosuppression, splenectomy
- - - - Fe deficiency
        
        1st line = PO galfer, 2nd = IV Ferrinject
      - B12 deficiency
        
        oral B12 or IM hydroxocobalamin
        
        always replace before folate to prevent SCDC
    - - direct coombs test: AI haemolysis
      - Howell Jolly bodies