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Five challenges in the field of viral diversity and evolution - Coggle…
Five challenges in the field of viral diversity and evolution
The evolution of viruses allows us to predict their occurrence and challeges
We are still limited in predicting virus variants
The use of RNA viruses help in prediction of virus evolution
Scientists are still having trouble with understanding animal to human transmission
Lab experiments can provide useful info about repeatability/predictability of virus evolution
Directional selection produces parallel evolution in a lab environment
Deep mutational scanning and microfluidics has assisted in creating viral diversity
Experiments using tumoral cells typically provide an unnatural environment
Viral evolution rates can be taken from phylogenetic analyses and are dependent on measurement timescales
Fitness of a virus is linked to the rate at which a virus infects cells
Characterizing the virosphere will require us to...
How viral phylogenetic trees map different ecosystems
How ancestry of viral groups is connected
address how groups evolved from one another
Why certain viral features have evolved recurrently
Success of viral infection may depend on the presence of other viruses
Viruses often undergo inter-host transmission and intra-host dissemination, promoting coinfection
Virus-virus interactions typically take place when viruses share gene products
Horizontal gene transfers may be caused by coinfection
Sanjuán R, Illingworth CJ, Geoghegan JL, Iranzo J, Zwart MP, Ciota AT, Moratorio G, Gago-Zachert S, Duffy S, Vijaykrishna D. 2021 Five challenges in the field of viral diversity and evolution. Frontiers in Virology. [cited 2022 April 20]