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Ch15 Principles of Metabolic Regulation - Coggle Diagram
Ch15 Principles of Metabolic Regulation
Glucose Can Be Stored for Later Use as Glycogen
Glycogen can be made from excess blood glucose or recycling of glucogenic metabolites like lactate or certain amino acids.
Glycogen is degraded to glucose units for use in energy production
Glucose Residues Are Removed from Glycogen
Enzyme: Glycogen Phosphorylase
Dealing with Branch Points in Glycogen
Glycogen phosphorylase
Debranching enzyme
Glucose-1-Phosphate Must Be Isomerized to Glucose-6-Phosphate for Metabolism
Enzyme:phosphoglycerate mutase
Ser
Glucose-6-Phosphate Is Dephosphorylated in the Liver for Transport Out of the Liver
Glucose-6-phosphatase is sequestered in the ER lumen
concentration gradients for glucose and glucose-6-phosphate
Glycogen synthesis
Enzyme: glycogen synthase
UDP-Glucose Is the Substrate for Glycogen Synthase
:
G-1-P vs G-6-P
glycogen degradation
G-1-P➡️G-6-P
glycogen synthesis
G-6-P➡️G-1-P
Ser
Synthesis of Branches in Glycogen
Glycogenin Starts a New Glycogen Chain
Attach UDP nonstop
Integration of Glycogen Synthesis and Degradation
Control of Glycogen Breakdown
Glucagon
Epinephrine
activates glycogen phosphorylase
Control of Glycogen Synthesis
Insulin
stimulates the activity of muscle hexokinase
activates glycogen synthase
Glycogen Synthase Is Controlled by Phosphorylation
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