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Metabolism of Toxins - Coggle Diagram
Metabolism of Toxins
Biotransformation of Xenobiotics
Process
Characteristics
Biotransformation
Metabolism
Bioactivation
Mechanisms
Chemical Characteristics
Enzyme Characteristics
Predominantly present in Liver
2 Phases
Modification (Phase 1)
Polar
Reactive
Covalent binding to tissue macromolecules
Aim
Modify chemicals
Modest increase water solubility
Creating functional groups
OH
NH2
COOH
3 main types of rxns
Oxidation
Reduction
Hydrolysis
Conjugation (Phase 2)
Hydrophillic
Reactive
Covalent binding to tissue macromolecules
Aim
Make compound water soluble
Ready to be degraded
Excretion
Biomodification Enzymes
Factors
External
Diet
Smoking
Drugs
Internal
Organ-sprcific differences
Species Dep-Differences