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History & Principles of Toxicology - Coggle Diagram
History & Principles of Toxicology
Historical Perspective
History
3 phases
Phase 1
Fishing
Gathering
Hunting
Phase 2
Agricultural Developmet
Cooking allow cultivation of plants with natural toxins as crop
Storage and transport introed new toxic compounds such as moulds
Phase 3
Industrial Development
Distance b/w food source & consumer
Canning Preservation
Chemical additives
Preservation
Coloring
Legal steps guarantee food safety and quality
Figures
Paracelsus
Dose Response Curve
Pott
Reporting of carcinogen in workplace to target organ
PAHs
Principles
Dose
Dose Response Relationship
Dose Response Curve
What made toxicology socially relevant?
DDT
Silent Spring
Thalidomide
Agent Orange
3 major aims
Defining
Toxicity
MOA
Mechanisms of Actions
Struc Activity Rela
Eval health & environ hazard & risk
Advisory task
Autorities
Industries
Consumers
What is Risk Assesment?
Hazard Identification
Hazard Characterization
2.5 Exposure Assessment
Risk Characterization
Risk Managment
Definitions
Study of adverse [Toxic] effects of chemicals on living organisms
Knowledge essential for safe use of chemicals
Drugs
Additives
Novel food ingredients
Main Chemical Classes
PAHs
Poly aromatic Hydrocarbons
Dioxins
POPs
Persistent Organic Pollutants