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Toxicokinetics - Coggle Diagram
Toxicokinetics
What is Toxicokinetics
Terminology
Bioavailability
Fraction of dose that ends up in the general circulation
Toxicokinetics describes
rate chem enter body
Excretion of chem from body
Metabol of chem in body
What are pharmacokinetic models
Physiologically based kinetic model
PBK Model
What are needed to make the PBK models
Input
Physiological
Chem
Kinetic Constants
In vitro
Output
Predictions for metabolites at different ...
Oral Dose
Species
Organs
Indiv
Advantages
Flexible
Allow extrapolation with
Changing physiological parameters
Differences b/w species
Different dosing regimes
Provide time course of distribution to any organ/tissue
Classical Toxicokinetics
1 compartment model
2 compartment model
