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Blood - Coggle Diagram
Blood
WBC count
Leukopenia
Production decrease
Inhibit Hematopoietic stem cells
RBC decrease
RBC defect
Bone marrow increase
Inhibit Granulocytic precursors
granulocyte decrease
Congenital disease
Destruction/ Sequestration
Autoimmue disease
Leukocytosis
Production increase
Storage pool release
Margination decrease
Extravasation decrease
Clinical meaning
Monocytosis
Chronic infection
Eosinophilia
Allergy
Neutrophilic leukocytosis
Acute bacterial infection
Lymphocytosis
Chronic immune style stimuli
Hematological Neoplasms
Chromosomal translocation
Chimeric protein
BCR-ABL hybrid gene
9/22 translocation
New tyrosine kinase, which can be inhibited
Example
Chronic myeloid leukemia(CML)
Overexpression
8/14 translocation
IG gene + MYC oncogene
MYC overexpression
Example
Burkitt lymphoma
Chronic inflammation
Helicobacter pylori
Gastric MALT lymphoma
Autoimmune diseases
Viruses
HTLV-1
adult T cell leukemia/lymphoma
HHV-8 (Kaposi sarcoma associated herpes virus)
Primary effusion lymphoma
RARE
EBV
Burkitt lymphoma
Hodgkin lymphoma
Nasal type NK/T cell lymphoma
Lymph node