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cancer cell signaling - Coggle Diagram

- - - - receptor
        
        tyrosine kinase receptor
        
        癌細胞中多屬此類
        
        傳訊方式(正常時)
        
        transphosphorylation
        
        當lignad(GF)到達後tyrosine kinase domain 會dimerization以傳遞signaling
        
        當tyrosine kinase receptor變為oncoprotein
        
        導致tyrosine kinase receptor癌化的原因
        
        mutation
        
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        amino acid substitution
        
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        overexpression
        
        2 more items...
        
        truncation of ectodomain
        
        1 more item...
        
        舉例
        
        EGF-R(epidermal growth factor receptor)
        
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        integrin receptor
        
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        TGF-β receptor
        
        3 more items...
        
        Notch receptor
        
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        G-protein coupled receptor
        
        Ras protein
        
        和G proein的a-subunit相似
        
        Ras-GDP=off
        
        1 more item...
        
        GEF : 讓Ras-GDP變成Ras-GTP
        
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        1.EGFR&EGF結合，EGFP磷酸化
        
        2.吸引GRB2(含SH2,3)& SOS
        
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        突變
        
        第12個glycine突變
        
        1 more item...