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Wear and tear, includes, leads to, leads to, include, includes, check,…

- - - - the metacarpophalangeal (MCP)
      - proximal interphalangeal (PIP) joints
  - - - Nail pitting
      - onycholysis
- - - - Degeneration of the articular cartilage
    - - Chondrocyte injury
- - - - Staphylococcus aureus
        
        Gram positive cocci in clusters
        
        facultative anaerobic bacteria
        
        β- hemolytic
        
        Catalase positive
        
        Coagulase positive
      - Streptococci
    - - Hemophilus infuenzae
      - Kingella kingae
        
        Gram negative coccobacilli, fastidious, facultative anaerobic bacteria
        
        Resides in human oropharynx
        
        Oxidase positive
  - - - S. aureus
      - Streptococcal species
      - Neisseria gonorrhea
    - - Fungal species
      - Mycobacterial species
      - Gram-negative bacteria
        
        Including pseudomonas aeruginosa
- - - - Salicylic acid
      - Diclofenac
  - - - non selective
      - cox 2 inhibitor