Please enable JavaScript.
Coggle requires JavaScript to display documents.
Bovine Viral Diarrhea Virus, : - Coggle Diagram
Bovine Viral Diarrhea Virus
Flaviviridae, Pestivirus
Pestivirus A, B, C
BVDV type 1 & 2
Europe: Type 1
US: 1 & 2
Non-cytopathic
No morphologic change in infected cells
Cytopathic
Cell death
NS2, NS3
Infected during pregnancy
Before 2 mths
abortion
After 4 mths
Abortion
Between 2-4 mths
Immunotolerance
PI Calf
Poor doer
Recurrent disease
Sheds virus entire life
Die within a year
Cytopathic form mutation
Mucosal disease
Death
Clinical Presentation
Young animals just arrived on lot
Respi dz
Biphasic fever
Lymphopenia
Diarrhea
Thrombocytopenia
Hemorrhage
Infected pregnant cow
abortion, malformations
Adult with persistent infection
Immunosuppression
Poor performance
Mucosal disease
Subclinical!
Dx, Control, Treat
Samples: Whole blood, swabs, feces, fetus, ear notch
RT-PCR, virus isolation, ear notch ELISA
Milk testing
Abs = herd with recent infection
Virus = herd with current infection
Paired sera
PI vs transient infection
: