Please enable JavaScript.
Coggle requires JavaScript to display documents.
Principles of Metabolic Regulation - Coggle Diagram
Principles of Metabolic Regulation
Glucose Can Be Stored for Later Use as Glycogen
branched polymer of α(1->4)-linked glucose with α(1->6) linkages every 12 to 14 glucose units
sorage in
liver
muscle
Glucose Residues Are Removed from Glycogen by Glycogen Phosphorylase
Dealing with Branch Points in Glycogen
Glycogen phosphorylase
work until it reaches four residues from an (a1-> 6) branch point
Debranching enzyme
transfers a block of three residues to the nonreducing end of the chain
cleaves the single remaining (a1->6)-linked glucose
Glucose-1-Phosphate Must Be Isomerized to Glucose-6-Phosphate for Metabolism
Glucose-6-Phosphate Is Dephosphorylated in the Liver for Transport Out of the Liver
Glycogen Synthesis from Glucose
Blood glucose must be
phosphorylated
labeled with UDP
added to glycogen
Glycogen Is Synthesized by Glycogen Synthase
UDP-Glucose Is the Substrate for Glycogen Synthase
Glucose-1-Phosphate Is the Substrate for NDP-Sugar Pyrophosphorylase
Control of Glycogen
Breakdown
Glucogon/epinephrine
activates glycogen phosphorylase
cleaves glucose residues of glycogen, generating glucose-1-phosphate.
Synthesis
Insulin
stimulates the activity of muscle hexokinase
enables activation of glucose.
activates glycogen synthase
energy storage
