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Akut Renal Allograft Rejection - Coggle Diagram
Akut Renal Allograft Rejection
tanım
doku nakli yapılan organdakıi baozulma
2 tür
Acute T-cell mediated rejection
Acute B cell-mediated rejection
Subclinic rejection
Hyperacute rejection
risks
Low risks
Living donör tx
First tx
Between relatives
From wife to husbands
İdeal donör
Short cold ischemia
From mother to child
High risk
deceased donör
2, 3 tx
Unrelated tx
Fro husband to wife
Elderly, hypertensive donör
Long cold ischemia
From child to mother
Pra+ dsa+ xm+ abo incompatible
Pregnancy
History of transfusion
İnfection
Clinical manifestation
mos of them aseympthomatic
Change in ürine color and output
New onset or worsening of proteinuria
increase in blood pressure
Plasma donor derived cell free dna >%1
Rarely high fever pain in the graft area tenderness
Nonspesifik finding renal dopple us
İncrease Rİ values
Disruption of paranchimal echogenety
The gold standart in diognosis is graft biopsy
Serum creatinine level, diuresis Antibodies in follow up
pathogenesis
Cellular theory
İmminological reason
CD8
Mhc 1 tanır
ifn gama üretir
Granzim ve perforin yoluyla stotksite oluşturur
cd4
Mhc 2 tarafından sunulan peptid tanınır
th1
İFN gama İL2 TNFa Greftte infiltrat olarak bulunur
th2
İL4 İL 5 İl10 B hücre gelişimine ve İg E- eizonofil üretimine yardımcıdır
Thücrelerin ürettiği sitokinler daha çok t hücresi çeker
humaral theory
antibodies ler tarafından yaoılır ki bunlar önce anında ve sonmra oluşmuş olabilir0