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acne - Coggle Diagram
acne
medication
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benzoyl peroxide that reduces the sebum production, act as antibacterial by suppressing the propionibacterium acne, depresses inflammatory lesion, and also stimulates breakdown of the accumulate plug formed.
vitamin a acid, tretinion : topically applied to clear the skin plug. it plays role in celluilar turnover as it forces out the foliicular plug and prevent the formation (comdome)
tetracycline, minocycline and clindamycin
estrogen therapy to reduce oily skin by sebum production ( estrogen-dominant oral contraceptive compound given
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clinical manifestations
white heads formed due to accumulation of impacted lipids, oils and proteins in the follicular ducts
appears small, whitish papules with minimal follicular opening
rupture of closed comdome due to action of propioni-bacterium acnes causes inflammatory reactions due to entry of follicular contents into dermis leading to erythromatous pustules, inflammatory papules and inflammatory cyst formation
open comdomes or black heads caused due to accumulation of debris, dirt, epithelial cells and bacterial accumulation
appears during pubertal and adolescence age 12- 35 years, earlier in women
androgenic action or adrenal glands stimulating the sebaceous gland secretions heightened at this age
pathophysiology
during pubertal and adolescence age, androgen(adrenal glands) stimulates the sebaceous gland that enlarges the size as well as causes excessive production of sebaceous oil, lipids and proteins that rises up to the top of the hair follicles and even flows out to the skin. so androgenic stimulation producing heightened response of sebaceous gland causes acne formation when accumulated sebum forms plug on the pilo-sebaceous duct. this plug material form comdones that grows its severity everyday.
follicular disorder affecting the susceptible hair follicles and most commonly seen over the face, neck and upper trunk