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SYSTEMIC LUPUS ERYTHEMATOSUS - Coggle Diagram
SYSTEMIC LUPUS ERYTHEMATOSUS
definition
Autoimmune disease involving multiple organs.
characters
characterized by autoantibodies, particularly antinuclear antibodies.
Typically chronic, may be acute.
Very heterogeneous.
Female-to-male ratio 9 : 1
etiology and pathogenesis
Failure of the mechanisms that maintain self-tolerance
Genetic Factors
• First degree relative
Concordance
HLA-DQ
Immunologic Factors
• Failure of self-tolerance in B cells
CD4+ helper T cells
Type I interferons
Environmental Factors
• Ultraviolet (UV) light
Drugs
clinical manifestations
hematologic
Arthritis, arthralgia or myalgia
Skin
Fever
Fatigue
Weight loss
Renal proplem
MORPHOLOGY
• Microscopy
Proliferation of Mesangial, Endothelial, and Epithelial cells.
Hematoxylin bodies.
• Hyaline thrombi (fibrinoid necrosis.
Wire-loops deposits.
Laboratory tests
Complete blood count.
Kidney and liver assessment.
Erythrocyte sedimentation rate.
Urinalysis.
Antinuclear antibody (ANA) test.
