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Adaptive immune system part A - Coggle Diagram
Adaptive immune system part A
Antigens and immunoglobulins
Antigenic receptors
Not always immunogenic
Proteins
Antibodies
Activities
Activate complement
Cleaves and activates C3
C3b
Activate phagocytic cells (opsinisation)
More than 1 antibody needed
Acute inflammatory response
Mast cells
Chemotaxis
Vascular permeability
Blocks microbial reactions
Blocks virus binding
Blocks receptor
Blocks toxin binding
Surface molecules
MHC I
Nearly all cells
MHC II
Antigen presenting cells
Mononuclear macrophages
B cells
Recognise self
Identify infected cells
Communicate
No MHC
Killed
NK cells
T cell receptors
Detect antigen if bound to MHC
T helper cell
Activates macrophages
Th-TCR
Interacts with MHC + foreign peptide
Release activating factors
Killing mechanisms
Cytotoxic T cells
Kill virus-infected cells
Interact with MHC I
Killing substances
NK cells
No MHC
PRR
Chance of binding lower
Extracellular killing of large microbes
Helminths
Antibody-dependent cellular cytotoxicity
Killing mechanisms
Macrophages
Reactive oxygen intermediates
NK cells
Granzyme
Eoisinophils
Perforins
Local defences at mucosal surfaces
IgA
Secreted antibody
Stops attachment