Please enable JavaScript.
Coggle requires JavaScript to display documents.
Hypersensitivity and autoimmunity - Coggle Diagram
Hypersensitivity and autoimmunity
Hypersensitivity
Over-activated
Allergies
Types
Immediate
Mins-24 hrs
Type I
Type II and III
Delayed
Type IV
24hrs-days
Autoimmunity
Failure to recognise own molecules as self
Loss of tolerance
Immune responses
Own cells
Genetic susceptibility
Infections
Autoantibodies
Delete auto-reactive lymphocytes
Molecular mimicry by invading microbes
Hypersensitivity (I)
Immediate
Allergen
Mast cells/basophils
Established
Atopy
Allergic reactions
Genetic?
IgE
Hygiene hypothesis
Not interacting with dirty environment enough
Mechanism
Sensitation phase
Activation phase
Effector phase
Tolerance
Non-reactivity
Self molecules
Reactivity
Autoimmune reactions
Damage
Mechanisms (deleted)
Self-reactive
T cells
Thymus
B cells
Bone marrow
Th cells
Tregs
Hypersensitivity (II)
IgG/igM
Bind to:
Host cells
Extracellular proteins
Foreign proteins on host cell
Complement and immune cells
Mins-24 hrs
Types:
Complement activated reactions
Antibody-dependent cell-mediated cytotoxicity
Anitbody-mediated cell dysfunction
Hypersensitivity (III)
IgG/IgM
Antibody complexes
Deposited in tissue
Complement
Neutrophils
Mins-24 hrs
Immune complexes
Hypersensitivity (IV)
Cell-mediated
Th1 cells secrete cytokines
Macrophages and Tc cells
24 hrs to days
Types:
Contact hypersensitvity
Tuberculin-type reaction
Granulomatous hyper-reaction