Please enable JavaScript.

Coggle requires JavaScript to display documents.

Granny's Fall, includes, caused by, increases, manifest as, includes,…

- - - - Senile
      - Postmenopausal
  - - - Genetic factors
      - Age-related changes
      - Reduced physical activity
      - Estrogen deficiency
        
        secretion of IL-6, TNF, and IL-1
      - Calcium deficiency
- - - - hold bone together while it heals
  - - - normal hip socket
  - - - DVT
      - PE
      - MI
      - stroke
- - - - Ischium
        
        Acetabulum
        
        Head of femur
        
        Hip joint
      - Pubis
      - Ilium
  - - - Between sacrum and ischial tuberosity
    - - between sacrum and ilium
    - - Between sacrum and ischial spine
  - - - Main abductors + prevent pelvis from dropping on unsupported side
    - - External rotators
    - - Extenstion and external roration
      - Inferior gluteal nerve
- - - - cholecalciferol to calcidiol
  - - - Calcidiol to calcitriol
- - - - Alendronates
      - Risedronate
      - Ibandronates
      - Zoledronate
      - Etidronates
    - - Hydroxyapatite crystals
      - Mevalonate pathway
        
        Farnesyl diphospahte Synthase and Geranyl diphosphate synthase
        
        Rho,Rac,Rab,Cdc4
      - Prevent osteoblast apoptosis
      - Increase Bone Density and Reduce Fractures
    - - Esophgus inflammtion
      - Esophgus Ulceration
  - - - Raloxifene
      - Bazedoxifene
    - - Binds to the Estogen Recptor Where it has fewer sides Effect than Estrogen Thearpy
    - - Leg Cramps
      - Hot Flashes
      - Venous Thrombosis
  - - - Denosumab
        
        Oral adminstration
        
        Mechanism of Action
        
        Inhibit activation of Osteoclast
        
        Inhibit RANKL and M-CSF
        
        Activates OPG
        
        Side Effects
        
        Bone, joint or muscle pain
        
        Osteonecrosis
        
        Hypoclacemia
      - Romosozumab
        
        multiple fragility fractures
        
        subcutaneous adminstration
        
        Mechanism of Action
        
        Side Effects
        
        cardiovascular events (cardiac ischemic and cerebrovascular accidents)
- - - - shortened and externally rotated leg