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Prognosis - Coggle Diagram
Prognosis
Total Number of Lymph Nodes
Significant association between MSI phenotype and high LN yield stage II- III
low BMI is associated with increased LN yield
Proximal tumor location
moderately differentiated histology
stage IIIC
Mutation of KRAS
borderline significant : further study
Histologic Type
Signet ring carcinomas
mucinous tumors
neuroendocrine tumors
Medullary carcinoma
MSI-H :more favorable prognosis
Microscopic Nodal Metastases
poor prognostic variable
Blood or LVI
At least 3 blocks of tumor (optimally>5) each have a single
section examined using H&E stain
Histologic Grade
Sentinel Node Analysis
Microsatellite Instability:15%
BRAF:8% to 10%
CpG Island Methylator Phenotype
Allelic Loss of 18q (DCC Gene Loss)
Host Lymphoid Response
CEA
Obstruction and Perforation