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Skin Functions - Coggle Diagram
Skin Functions
Immune defence
Physical barrier
Keratinocytes make antimicrobial peptides (AMPs)
Defensins, Cathelicidins, and members of Granin family
Langerhans cells
Trap antigens-> Lymph-> T cells
Cytokines
Secreted by:
Keratinocytes
Lymphocytes
Macrophages
Regulate inflammatory + immune responses
Acid pH of sweat and stratum corneum
Sebaceous Secretions Fungistatic
Dermcidin (AMP) produced by eccrine sweat glands activates Keratinocytes to make
Sensation
Free Nerve endings (DANGER)
Heat/Pain
Specialised
Pressure/Vibration/Touch
Autonomic
Sweat glands/Arrector Pili/Blood vessels
Temp Regulation
Vaso: constrict/dilate
Sweat evaporation
Vit D Production
7-dehydrocholesterol Photoactivated-> D3
Metabolised Liver (to 25-(oH)D3) Kidney ACTIVE (1,25-(oH)2D3)
Osteomalacia/Osteoporosis/Rickets
UV protection
Melanin protects Keratinocyte Nuclei
Absorb + Scatter UV rays
Scavenge Free Radicals
Enzymes repair damaged DNA
Prevent H20 loss
Staratum Corneum: overlapping cells/intercellular lipid
Aesthetic