Estrogen is produced by the ovaries, adrenal cortex, and placenta with progesterone, is responsible for secondary sex characteristics like breast development, increased vascularization, different distribution of fat, triggered by ovaries to release, which is controlled by puberty, at as early as ten years old the hypothalamus secretes gonadotropin, which stimulates the anterior pituitary gland which then releases lutenizing hormone ( a burst of this causes ovulation) and follicle stimulating hormone which assists the reproductive system, while progesterone, released in the same way as estrogen, helps trigger uterine changes during the menstrual cycle, estrogens also raise during the menstrual cycle,