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Meta-regression - Coggle Diagram
Meta-regression
Other studies
Lemiale
Fall in mortality over time
Cooper
Fall in mortality in cancer patients but not non cancer patients
Therefore is there something happening in cancer patients that's improving survival i.e. not just realated to sepsis campaigns
Liu
Fall in mortality over time
Rhee
Report difference in claims based vs clinical based studies
Hensley
Fall in mortality over time
Cancer patients more likely to die younger than non-cancer patients
Studies are not easily comparable as they use different definitions of sepsis
Trends
Decrease in mortality over time
HMS
IMS
IMSS
No trend for HMSS
Inverse relationship between age and hospital mortality from sepsis
Explained by proportion of haematological patients
Interpretation
Decrease in mortality over time
Reasons
Better awareness of sepsis
Surviving sepsis campaign
?Less toxic cancer treatments
?Better antimicrobials in cancer patients
Shift away from palliative approach as cancer survival improves
Better awareness specifically in cancer patients, more likely to present earlier