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Obesity drugs when-drugs-dont-work-in-overweight-people-722x406 - Coggle…
Obesity drugs 
Orlistat
Mechanism of action
when lipase activity is blocked,triglycerides from the diet are not hydrolised into absorbable free fatty acids and instead excreated unchanged
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Indications
it is indicated for obesity management including weight loss and weight maintanance when used in conjunction with a reduced calorie diet.
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Sibutramine
Mechanism of action
It exerts its pharmalogical actions predominantly via its secondary M1 and primary M2 amine metabolities.
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References
Goldman L, et al., eds. Obesity. In: Goldman-Cecil Medicine. 26th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed May 3, 2021.
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Kellerman RD, et al. Obesity in adults. In: Conn's Current Therapy 2021. Elsevier; 2021. https://www.clinicalkey.com. Accessed May 3, 2021.
Phentermine
Mechanism of action
Phentermine is an adrenergic agonist that promotes weight loss by activation of the sympathetic nervous system with a subsequent decrease in food intake and increased resting energy expenditure. The combination has been shown to have additive weight loss efficacy.
Indications
Phentermine Hydrochloride Tablets are indicated as a short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction in the management of exogenous obesity for patients with an initial body mass index ≥ 30 kg/m2, or ≥ 27 kg/m2 in the presence of other risk factors (e.g., controlled hypertension, diabetes, hyperlipidemia).
Nursing considerations
Contraindications
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glaucoma, an increased pressure in the eye.
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