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MALE AND FEMALE HORMONAL DRUGS Estrogens-604x270 - Coggle Diagram
MALE AND FEMALE HORMONAL DRUGS
Cyproterone actate(antiandrogen)
Name
Androcur
Mechanism of action
Cyproterone acetate inhibits competitively the effect of androgens on androgen-dependent target organs. it shields the prostate from the effect of androgens originating from the
gonads or the adrenal cortex. Prostatic carcinoma and itsmetastases are in general androgen-dependent, Androcur exerts a direct antiandrogenic action on the tumour and its metastases.
Cyproterone acetate has a progestogenic action exerting a negative feedback effect centrally on the hypothalamic receptors so leading to a reduction in gonadotropin release
and to diminished production of testicular androgens Treatment with cyproterone acetate in men results in a reduction of sexual drive and potency and inhibition of gonadal function. These changes are reversible following discontinuation of the therapy.
Indications
In men androgens help cancer cells to grow in some types of prostate cancer. By blocking these hormones may slow orstop the growth of cancer. may also be used after surgical
removal of testes to treat side effects such as hot flushes and to prevent any initial worsening of the disease.
In women, androgens may increase hair growth, loss of scalp hair and secretion of oil from the sweat glands. By blocking these hormones and may slow or stop excessive hairiness,
loss of scalp hair, acne and oily skin.
Nursing considerations
Contraindications
Pregnancy, lactation, and breastfeeding
Liver diseases and liver dysfunction
Chronic kidney disease
History of jaundice or persistent pruritus during pregnancy
Wasting syndromes (except in inoperable prostate cancer)
Severe depression
Side effects
tiredness, fatigue
weight change
headache
depressive mood
nausea and other gastrointestinal complaints
breast enlargement in men
decreased sexual drive
Storage conditions
Keep your tablets in a cool dry place where the temperature stays below 30°C
Route of administration
oral administration
intramuscular injection
Estriadol Benzoate (estrogen)
Name
Progynon-B
Mechanism of action
principal intracellular human estrogen and is substantially more potent than its metabolites
estrogen is produced by conversion of androstenedione,secreted by the adrenal cortex, to estrone in the peripheral tissues.
Estrogens act through binding to nuclear receptors in estrogen-responsive tissues
Circulating estrogens modulate the pituitary secretion of the
gonadotropins, luteinizing hormone and follicle stimulating hormone through a negative feedback mechanism. Estrogens act to reduce the elevated levels of these hormones seen in postmenopausal women.
Indications
decrease of oxytocin after menopause
osteoporosis
hot flushes ( hot face or chest and neck)
Nursing considerations
Contraindications
Contraindications of estrogens include coagulation problems,cardiovascular diseases, liver disease, and certain hormone sensitive cancers such as breast cancer and endometrial cancer.
nausea, vomiting, bloating, increased weight, water retention,
breast tenderness, vaginal discharge, heavy legs, and leg
Side effects
irritation
joint pain, stiffness, or swelling
vaginal bleeding
redness or swelling of the breast
tightness in the chest
sore on the skin of the breast that does not heal
Storage conditions
Store the medicine in a closed container at room temperature
away from heat, moisture, and direct light
Store at 20-25°C (68-77°F)
keep from freezing
Route of administration
Intramuscular injection
subcutaneous injection
intraviginal administration
References
Google.estriadolbenzanoatemedication.com(wikipedia)
Chen X, Ji ZL (2002): Therapeutic Target Database. Nucleic
Acids
Androcur Consumer Medicine Information. Pacific
Highway Pymble, Bayer Australia Pty Ltd. March 2013
Androcur Product Information. Pacific Highway Pymble
Bayer Australia Pty Ltd. November 2010
