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Topical drugs for skin Screenshot_20220318_091413 - Coggle Diagram
Topical drugs for skin 
Clindamycin
Indication
used to treat a wide variety of bacterial infections. It is an antibiotic that works by stopping the growth of bacteria
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Mechanism of action
Clindamycin works primarily by binding to the 50s ribosomal subunit of bacteria. This agent disrupts protein synthesis by interfering with the transpeptidation reaction, which thereby inhibits early chain elongation
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Anthralin
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Mechanism of action
A topical agent that binds DNA, inhibiting synthesis of nucleic protein, and reduces mitotic activity. Therapeutic Effect: Results in damage to DNA sugar and enhances membrane lipid peroxidation, which may play a critical role in the antipsoriatic action.
Clotrimazole
Indications
used to treat skin infections such as athlete's foot, jock itch, ringworm, and other fungal skin infections (candidiasis).
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Mechanism of action
Clotrimazole exerts its action primarily by damaging the permeability barrier in the fungal cytoplasmic membrane.Clotrimazole thereby inhibits the biosynthesis of ergosterol in a concentration-dependent manner by inhibiting the demethylation of 14 alpha lanosterol.When ergosterol synthesis becomes inhibited, the cell can no longer construct an intact and functional cell membrane. Ergosterol also directly promotes the growth of fungal cells in a hormone-like fashion; therefore, the rapid onset of the above events leads to a dose-dependent inhibition of fungal growth.
Fluconazole
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Mechanism of action
Fluconazole works by altering the fungal cell membrane. It exerts its fungistatic effect by selectively inhibiting 14-alpha demethylase. This is a cytochrome P-450 enzyme that is necessary for synthesizing ergosterol, which is an important component of the fungal cell membrane. 14-alpha demethylase converts lanosterol to ergosterol. Without ergosterol, 14 alpha-methyl sterols increase which subsequently causes the fungal cell membrane to exhibit increased cellular permeability. This causes the components inside the cell to leak.
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Definition
Drugs used reduce conditions which include oral medication, ointments, gels, injections, creams atc.
REFERENCES
Stephanie, S. Gardener, M.D. On April 14, 2021
www.webmd.com/skin-problem