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Immunesuppressant drugs immunosuppressant-drugs_thumb-1 - Coggle Diagram

- - - - sirolimus inhibit T lymphocytes activation and proliferation that occur in response to antigenic and cytokine, stimulating by mechanism that distinct of other immunosuppressants. Sirolimus
        also inhibit antibody production. In cell sirolimus bind immunophilins, fk binding protein -12 to
        degenerate an immunosuppressive complex.This complex binds to and inhibit the activation of mammalian targets of rapamycin (mTOR)
    - - lymphanglolelomymatosis
      - prophylaxis of renal transplant rejection
    - - contraindication
        
        contraindicated to patiens with eseconditions
        
        fluid retention
        
        liver problems
        
        malignant tumor
        
        pneumonia caused by pneumocystis jirovecii
        
        disease caused by cytomegalovirus infection
      - side effect
        
        changes in skin in skin
        
        accumulation of pus
        
        abdominal pain
        
        black or tarry stool
      - storage conditions
        
        25 degrees celcius
      - Route of administration
        
        administered orally
- - - - calcineurin activates transcription of IL 2 (interleukin 2) ciclosporin binds with cytosolic cyclophilin to form a complex which inhibits calceneurin
    - - Kidney, liver, heart transplant rejection
    - - contraindication
        
        allergic to cyclosporine and these conditions
        
        A mother who is breast feeding
        
        severe or uncontrolled Blood pressure
        
        seizures
        
        malignant lymphoma
        
        High amount of bilirubin in blood
      - side effect
        
        unusual hair growth, headache
        
        elevated blood pressure
        
        nausea or vomiting, diarrhoea
        
        unusual growth or swelling in gums
      - Storage condition
        
        25 degrees celcius
      - Route of administration
        
        administered orally
- - - - azathioprine antagonizes purine metabolism and may inhibits synthesis of DNA, RNA and proteins. It also interferes with cellular metabolism and inhibits mitosis. Its mechanism of action is likely due to incorporation of thiopurine analogues into the DNA structure, causing structure, termination and cytotoxicity
    - - homotransplantation
      - rheumatoid arthritis
      - prevention of rejection in renal homotransplantation
    - - Contraindications
        
        significant anemia
        
        decreased blood platelets
        
        a blood clot in a vein of the liver
        
        severe decrease in white blood cells
      - Side effects
        
        fever, night sweat,weight loss, tiredness
        
        loss of appetite
        
        sore throat
        
        burning with urination or dysuria
      - Storage conditions
        
        25 degrees celcius
      - Route of administration
        
        administered orally
- - - - Daclizumab function binds with high-affinity IL-2 receptor complex and inhibit IL-2 receptor sub-unit is expressed on activated but not resting lymphocytes
    - - prophylaxis of acute organ rejection
      - multiple sclerosis
    - - contraindication
        
        contraindicated to patient with liver impairment,elevated ALT,AST and autoimmune hepatitis
      - side effect
        
        sore throat, coughing or signs of infection
        
        fever or chills
        
        dizziness, headache, swelling of feets
      - Storage conditions
        
        the prefilled syringe should be be stored in refrigerator between 2 to 8 degrees Celsius. it must not be frozen of be exposed temperature above 30 degrees celcius
      - Route of administration
        
        intravenously and subcutanously in treatment of multiple sclerosis